3/24/2024 0 Comments Csc orion 18 pak![]() Musarin demonstrated tyrosine kinase inhibitory activity in vitro. Through whole transcription profile and gene enrichment analysis of musarin-treated CSCs-like cells, major signaling pathways and network modulated by musarin have been enriched, including the bioprocess of the Epithelial-Mesenchymal Transition, the EGFR-Ras signaling pathway and enzyme inhibitor activity. Furthermore, Musarin, in particular, strongly inhibits aggressive human colorectal cancer stem cell-like CD24 +CD44 + HT29 proliferation in vitro and in a NOD/SCID murine xenograft model. The protein sequence of musarin was determined through enzyme digestion and MS/MS analysis. In this study, we characterized a novel 12-kDa protein that named musarin, which was purified from Trametes versicolor mushroom extract and showed significant growth inhibition on multiple human colorectal cancer cell lines in vitro. Trametes versicolor mushroom extract demonstrates strongly cell growth inhibitory activity on human colorectal tumor cells. Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer. Colorectal cancer is the second deadly cancer in the world. ![]()
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